Recombinant Human CD114/CSF3R Protein, His Tag

CSF3R

Q99062

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

Granulocyte Colony Stimulating Factor Receptor (G-CSFR) which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. G-CSFR mediates the specific effect of G-CSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis.

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