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Recombinant Human CD266/TNFRSF12A Protein, Fc Tag

Recombinant Human CD266/TNFRSF12A Protein, Fc Tag

Item no.	KMD-KMH415-50ug
Manufacturer	KMD Bioscience
Amount	50 ug
Category	Oncology By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
Host	Mammalian cell
Conjugate/Tag	Fc
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FN14, CD266, TWEAKR, TNF receptor superfamily member 12A
Available
Molecular Name	TNFRSF12A
Source	This protein contains the human TNFRSF12A(Glu28-Trp79) was fused with the C-terminal Fc Tag and expressed in Mammalian cells.
Uniprot Accession	Q9NP84
Purity	>=90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Buffer	PBS
Purification	Protein A/G
Predicted Molecular Weight	30.72kDa
Background	TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 exerts an apoptotic activity in HT-29 human adenocarcinoma cells whilst cultured in the presence of IFN. TNFSF12 promotes proliferation and migration of endothelial cells.
Storage	Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 9/18/2025

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