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Recombinant Human TNF Protein, His Tag

Recombinant Human TNF Protein, His Tag

Item no.	KMD-KMH494-50ug
Manufacturer	KMD Bioscience
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
Host	Mammalian cell
Conjugate/Tag	His
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha, tumor necrosis factor
Available
Molecular Name	TNF
Source	This protein contains the human TNF(Val77-Leu233) was fused with the N-terminal His Tag and expressed in Mammalian cells.
Uniprot Accession	P01375
Purity	>=90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Buffer	Supplied as solution form in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl./ Lyophilized from 50 mM Tris-HCl, pH 7.5, 150 mM NaCl.
Purification	Protein A/G
Predicted Molecular Weight	17.32kDa
Background	Tnf is secreted bymacrophages, monocytes, neutrophils, T-cells, NK- cells following theirstimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF- alpha. Stimulatedperipheral neutrophilic granulocytes but also unstimulated cells and also anumber of transformed cell lines, astrocytes, microglial cells, smooth musclecells, and fibroblasts also secrete Tnf. Human milk also contains thisfactor. The synthesis of TNF-alpha is induced by many different stimuliincluding interferons, IL2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and PAF (platelet activating factor).
Storage	Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 9/18/2025

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