Recombinant Human HAVCR2 Protein, His Tag

HAVCR2

Q8TDQ0

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFNgamma secretion and influences the ability to induce T cell tolerance in both mice and man.

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