Recombinant Human ACVR1 Protein, His Tag

ACVR1

Q04771

< 1.0 EU per ug of the protein as determined by the LAL method.

Protein A/G

ACVR1 is a receptor serine/threonine kinase that is member of the ACVR family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ACVR1, but not TGFbetaRI (ACVR1), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1 pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.

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