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Recombinant Mouse IL-18bp Protein, Fc Tag

Recombinant Mouse IL-18bp Protein, Fc Tag

Item no.	KMD-MOP2205-50ug
Manufacturer	KMD Bioscience
Amount	50 ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Necrosis
Type	Proteins Recombinant
Specific against	Mouse (Murine, Mus musculus)
Host	Mammalian cell
Conjugate/Tag	Fc
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MC54L, Igifbp, IL-18BP, interleukin 18 binding protein
Available
Molecular Name	Il18bp
Source	This protein contains the mouse Il18bp(Thr29-Ala193) was fused with the C-terminal Fc Tag and expressed in Mammalian cells.
Uniprot Accession	Q9Z0M9
Purity	>=90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Buffer	PBS
Purification	Protein A/G
Predicted Molecular Weight	43.15kDa
Background	Mouse IL-18BP is a circulating glycoprotein, which functions as an IL-18 antagonist by binding to IL-18 with high affinity and neutralizing its biological activity. IL-18BP has no amino acid sequence homology to IL-18 or IL-1 receptors. The gene for human IL-18BP encodes at least four isoforms by alternative splicing. The IL-18BP isoforms A and C each contain one immunoglobulin (Ig)-like C2-type domain while isoforms B and D lack the complete Ig domain. The complete Ig domain has been shown to be essential for IL-18BPs binding and neutralizing properties. Several poxviruses have been shown to encode proteins with sequence similarity to human and mouse IL-18BPs that also bind and inhibit IL-18 bioactivities. This could lead to viral modulation of host immune responses.
Storage	Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 9/18/2025

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