Comparison

BAFF-R (CT) Blocking Peptide

Item no. LEIN-B504-50ug
Manufacturer Leinco Technologies
Amount 50 ug
Category
Type Peptides
Specific against Human (Homo sapiens)
Citations 1. Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 2003; 4:95-104.
2. Bruey JM, Bruey-Sedano N, Newman R, et al. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κB and caspase-1 activation in macrophages. J. Biol. Chem. 2004; 279:51897-907.
3. Agostini L, Martinon F, Burns K, et al. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
4. Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Shipping Condition Room temperature
Available
Manufacturer - Category
Control Peptides
Manufacturer - Targets
B-Cell Activating Factor Receptor
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description
BAFF receptor (BAFFR) is a type III transmembrane protein and member of the TNF receptor (TNFR) super family. It is highly expressed in spleen, lymph node, B-cells and peripheral blood leukocytes. BAFFR plays a role in nearly all stages of differentiation of B-cells from development to the maintenance of long-lived bone marrow plasma cells. BAFFR signals by activation of the NF-kappaB signaling pathway. Overexpression of the BAFFR ligand, BAFF, in mice leads to autoimmune characteristics similar to systemic lupus erythematosus (SLE) and Sjogren’s syndrome. Furthermore, high levels of BAFF have been detected in the serum of humans with SLE, rheumatoid arthritis, Sjogren’s syndrome and systemic sclerosis. Inhibition of BAFFR signaling with BAFFR-Ig has been successful in treating SLE and rheumatoid arthritis in mouse models. In addition misexpression of BAFFR brought about by retroviral integration has lead to leukemia in some strains of mice. This makes BAFFR an obvious candidate for further therapeutic investigation. Recombinant human BAFFR has a molecular weight of 7.7 kDa and contains 76 amino acid residues corresponding to the extracellular portion of the full native BAFFR.
Background
BAFF receptor (BAFFR) is a type III transmembrane protein and member of the TNF receptor (TNFR) super family. It is highly expressed in spleen, lymph node, B-cells and peripheral blood leukocytes. BAFFR plays a role in nearly all stages of differentiation of B-cells from development to the maintenance of long-lived bone marrow plasma cells. BAFFR signals by activation of the NF-kappaB signaling pathway. Overexpression of the BAFFR ligand, BAFF, in mice leads to autoimmune characteristics similar to systemic lupus erythematosus (SLE) and Sjogren’s syndrome. Furthermore, high levels of BAFF have been detected in the serum of humans with SLE, rheumatoid arthritis, Sjogren’s syndrome and systemic sclerosis. Inhibition of BAFFR signaling with BAFFR-Ig has been successful in treating SLE and rheumatoid arthritis in mouse models. In addition misexpression of BAFFR brought about by retroviral integration has lead to leukemia in some strains of mice. This makes BAFFR an obvious candidate for further therapeutic investigation. Recombinant human BAFFR has a molecular weight of 7.7 kDa and contains 76 amino acid residues corresponding to the extracellular portion of the full native BAFFR.
PubMed
B-Cell Activating Factor Receptor
Amino acid location
This peptide sequence is located at amino acids 169 to 183 of Human BAFF-R protein.
Concentration
0.2 mg/ml
Formulation
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ug
Available: In stock
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