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ZNRF3 Recombinant Protein

ZNRF3 Recombinant Protein

Item no.	PRS-11-135-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Western Blot Autophagy
Type	Proteins Recombinant
Format	Lyophilized
Applications	WB
Specific against	other
Conjugate/Tag	HIS
Purity	>95% as determined by SDS-PAGE.
Sequence	Lys 56 - Met 219
Citations	Hao H.X. et al. 2012. Nature. 485 (7397): 195–200. Serra S.& Chetty R. 2018. Journal of Clinical Pathology 71 (1): 1–6. Hao H.X. et al. 2016. Cancers (Basel) 8 (6).
NCBI	ZNRF3
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ZNRF3, Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203
Available
Manufacturer - Applications	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Conditions	Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Molecular Weight	19.7 kDa
Background	The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
Buffer	PBS, pH7.4
NCBI Official Name	zincandringfinger3
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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