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LGR4 / GPR48 Recombinant Protein

LGR4 / GPR48 Recombinant Protein

Item no.	PRS-11-136-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Metabolism Diabetes Glucose Homeostasis Peptides & Proteins Recombinant Proteins Obesity Western Blot ELISA
Type	Proteins Recombinant
Format	Lyophilized
Applications	WB, ELISA
Specific against	other
Conjugate/Tag	HIS
Purity	>85% as determined by SDS-PAGE.
Sequence	Ala 25 -Thr 544
Citations	Yue Z. et al. FASEB J. 2018. 32(5):2422-2437. Gao Y. et al. Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 2006 Dec 15; 66(24):11623-31. Gao Y. et al. 2009. Chin. J. Cancer 28, 104–107. Liang F. et al. 2015. Med Oncol. 2015 Mar;32(3):49.
NCBI	LGR4
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	LGR4, GPR48, G-protein coupled receptor 48, Leucine-rich repeat-containing G-protein coupled receptor 4
Available
Manufacturer - Applications	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.8 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Conditions	Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Molecular Weight	58.8 kDa
Background	The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs)-1–4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.
Buffer	PBS, pH7.4
NCBI Official Name	leucinerichrepeatcontainingGprotein-coupledreceptor4
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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