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TRAIL-R2 Recombinant Protein

TRAIL-R2 Recombinant Protein

Item no.	PRS-90-259-50ug
Manufacturer	ProSci
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Conjugate/Tag	Fc
Purity	>95% (SDS-PAGE).<br><br> Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Sequence	The extracellular domain of human TRAIL-R2 (aa 52-212) is fused to the Fc portion of human IgG1.
NCBI	TNFRSF10B
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DR5,TNFRSF 10B,CD262,Tumor Necrosis Factor Receptor Superfamily Member 10B,TRAIL Receptor 2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Stable for at least 6 months after receipt when stored at -20˚ C.
Biological Activity	Blocks human or mouse TRAIL activity in a concentration of 1-10ug/ml.
Background	TRAIL-R2 (DR5; CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
By Type	Apoptosis, Cancer, Homeostasis, Immunology, Other
Protein Gi #	2338419
Concentration	1mg/ml after reconstitution.
Buffer	Contains PBS. Reconstitute with 50 μ l sterile water.
Application Note	This recombinant proteins is for research use only.
NCBI Official Name	tumor necrosis factor receptor superfamily, member 10b
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human, Mouse
By Species	Human, Mouse

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 1/1/2026

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