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TNF-R1 Recombinant Protein

TNF-R1 Recombinant Protein

Item no.	PRS-90-260-50ug
Manufacturer	ProSci
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Conjugate/Tag	Fc
Purity	>95% (SDS-PAGE).<br><br> Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
Sequence	The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1.
NCBI	TNFRSF1A
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	p55,CD120a,TNFRSF 1A,Tumor Necrosis Factor Receptor Superfamily Member 1A,TNF Receptor 1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Stable for at least 6 months after receipt when stored at -20˚ C.
Biological Activity	TNF-R1:Fc fusion protein blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1ug/ml.
Background	TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
By Type	Apoptosis, Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction, Other
Protein Gi #	4507575
Concentration	1mg/ml after reconstitution.
Buffer	Contains PBS. Reconstitute with 50 μ l sterile water.
Application Note	This recombinant proteins is for research use only.
NCBI Official Name	tumor necrosis factor receptor superfamily, member 1A
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human, Mouse
By Species	Human, Mouse

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 1/1/2026

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