Comparison

IL-2 non-lytic Recombinant Protein

Item no. PRS-90-465-50ug
Manufacturer ProSci
Amount 50 ug
Category
Type Proteins Recombinant
Format Lyophilized
Specific against other
Conjugate/Tag Fc
Purity >98% (SDS-PAGE).<br><br> Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Sequence The extracellular domain of human IL-2 (aa 21-153) is fused to the N-terminus of the Fc region of a mutant human IgG1.
NCBI IL2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Interleukin-2,Aldesleukin
Shipping Condition Room temperature
Available
Manufacturer - Type
Recombinant Proteins
Shipping Temperature
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Biological Activity
Shows the biological function of the IL-2 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Background
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
By Type
Cancer, Chemokines & Cytokines, Immunology, Infectious Disease, Neuroscience, Signal Transduction, Stem Cell
Protein Gi #
28178861
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.
Application Note
This recombinant proteins is for research use only.
NCBI Official Name
interleukin 2
NCBI Organism
Homo sapiens
Disclaimer
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species
Human
By Species
Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ug
Available: In stock
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