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LTbetaR non-lytic Recombinant Protein

LTbetaR non-lytic Recombinant Protein

Item no.	PRS-90-536-100ug
Manufacturer	ProSci
Amount	100 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Conjugate/Tag	Fc
Purity	>98% (SDS-PAGE).<br><br> Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Sequence	The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1.
NCBI	LTBR
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Lymphotoxin-beta Receptor,Tumor Necrosis Factor Receptor 2 Related Protein,Tumor Necrosis Factor C Receptor,Tumor Necrosis Factor Receptor Superfamily Member 3,TNFRSF3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Biological Activity	Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Background	The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
By Type	Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Signal Transduction
Protein Gi #	4505039
Buffer	Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Application Note	This recombinant proteins is for research use only.
NCBI Official Name	lymphotoxin beta receptor
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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