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LR3-IGF-1 Recombinant Protein

LR3-IGF-1 Recombinant Protein

Item no.	PRS-91-017-0.05mg
Manufacturer	ProSci
Amount	0.05 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite By Cell Type Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Endocrine Regulation of Lipid Metabolism
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Conjugate/Tag	Tag Free
Purity	Greater than 95% as determined by reducing SDS-PAGE.<br />Endotoxin level less than 0.05 ng/ug (0.5 IEU/ug) as determined by LAL test.
Sequence	Gly49-Ala118
NCBI	IGF1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Insulin-Like Growth Factor I,IGF-I,Mechano Growth Factor,MGF,Somatomedin-C,IGF1,IBP1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized protein should be stored at -20˚ C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚ C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚ C for 3 months.
Molecular Weight	9.1 kD
Biological Activity	ED50 is greater than 200 ng/ml as determined by an IGF binding protein assay.
Background	Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
By Type	Other
Protein Gi #	767957252
Buffer	Lyophilized from a 0.2 um filtered solution of 300mM HAc-NaAc, pH 6.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 500mM Acetic Acid.
Application Note	This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name	insulin like growth factor 1
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 1/1/2026

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