UFM1 activating enzyme Recombinant Protein

N-6 His tag

Store at -20˚ C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localizes to the nucleus in presence of SUMO2.

Supplied as a 0.2 um filtered solution of 20mM TrisHCl pH 8.0, 1mM DTT, 10% glycerol, 50mM NaCl. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

ubiquitin like modifier activating enzyme 5

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Human