Amiloride-binding protein 1 Recombinant Protein

C-6 His tag

Store at -20˚ C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Amiloride-sensitive amine oxidase (AOC1) belongs to the copper/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.

Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

amine oxidase, copper containing 1

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Human