SARS-CoV-2 (COVID-19) S-trimer (D614G) Recombinant Protein

C-6His tag

Reconstituted protein solution should be store below -20˚ C.

The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at
the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute
respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion
required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been
reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human
ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1
mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.
S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of
neutralizing-antibody and T-cell responses, as well as protective immunity.

Supplied as a 0.2 uM filtered solution of PBS, pH 7.4

Surface glycoprotein

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