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CD273 Recombinant Protein

CD273 Recombinant Protein

Item no.	PRS-96-616-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience By Cell Type Blastoma Carcinoma Hematology Lymphoma Peptides & Proteins Recombinant Proteins Myelofibrosis Western Blot Butyrophilins Cytoskeleton Markers
Type	Proteins Recombinant
Format	Lyophilized
Applications	WB
Specific against	other
Conjugate/Tag	Fc
Purity	>95% as determined by SDS-PAGE more than 90% measured by SEC-HPLC.
Sequence	Leu 20 - Pro 219
Citations	Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846. Latchman Y., et al., 2001, Nat. Immunol. 2:261-268. He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.
NCBI	PDCD1LG2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	PDL2,PD-L2,Butyrophilin B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Manufacturer - Conjugate / Tag	C-Fc Tag
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight	49.2 kDa
Biological Activity	(1) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, Strep Tag at 2 ug/mL (100 ul/well) can bind Human PD-L2, Fc Tag with a linear range of 0.4-3 ng/mL. (2) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, His Tag at 0.2 ug/mL (100 ul/well) can bind Human PD-L2, Fc Tag with a linear range of 0.16-2.5 ug/mL.
Background	Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
By Type	Apoptosis, Immunology
Buffer	PBS, pH7.4
Application Note	This recombinant protein can be used for WB. For research use only.
NCBI Official Name	programmed cell death 1 ligand 2
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 2/5/2026

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