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LRRC32 Recombinant Protein

LRRC32 Recombinant Protein

Item no.	PRS-96-921-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Neuroscience Neuroinflammation By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Mesothelioma Western Blot ELISA By Organ Colorectal Cancer
Type	Proteins Recombinant
Format	Lyophilized
Applications	WB, ELISA
Specific against	other
Conjugate/Tag	Fc
Purity	>95% as determined by SDS-PAGE.<br><br>Endotoxin level is less than 1.0 EU per ug by the LAL method.
Sequence	His 20 - Asn 627
Citations	Battaglia, M., et al., 2009, Eur. J. Immunol. 39(12): 3296-3300. Wang, R. et al. 2008, PloS ONE 3(7): e2705. Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13(9B): 3343-3357.
NCBI	LRRC32
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GARP,Garpin,D11S833E
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Molecular Weight	92.6 kDa
Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
Background	Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
By Type	Immunology
Buffer	Tris with Glycine, Arginine and NaCl, pH7.5
Application Note	This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name	LRRC32 protein
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 12/4/2025

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