Comparison

IL-21 European Partner

Item no. RLT-R20-036S
Manufacturer ReliaTech
Amount 2ug
Category
Type Proteins Recombinant
Specific against Rat (Rattus norvegicus)
Host E.coli
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Available
Synonyms
IL21, Interleukin-21
Detection range
Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106 units/mg.
Description
IL?21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen?specific responses of immune cells. The biological effects of IL?21 include: inducing the differentiation of T cell?stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL?4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL?21 promotes the anti?tumor activity of CD8+ T cells and NK cells. IL?21 exerts its effect through binding to a specific type I cytokine receptor, IL?21R, which also contains the gamma chain (gammac) found in other cytokine receptors, including IL?2, IL?4, IL?7, IL?9 and IL?15. The IL?21/IL?21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Rat IL?21 is a 15.3 kDa protein containing 130 amino acid residues.
Formulation
lyophilized
Length (aa)
130
Protein Sequence
MHKSSPQRPD HLLIRLRHLM DIVEQLKIYE NDLDPELLTA PQDVKGQCEH EAFACFQKAK LKPSNTGNNK TFINDLLAQL RRRLPAKRTG NKQRHMAKCP SCDLYEKKTP KEFLERLKWL LQKMIHQHLS
NCBI GeneID
365769
Accession Number Protein
NP_001102413.1?
Accession Numberm RNA
NM_001108943.2
Uniprot
A3QPB9

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 2ug
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close