Radicicol, 1 MG

Radicicol is a macrocyclic antifungal antibiotic that inhibits protein tyrosine kinase. It binds to a highly conserved pocket in the Hsp90 (heat shock protein 90) chaperone protein and inhibit the intrinsic ATPase activity of Hsp90. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src , ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo , inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.

Clear colorless solution at 20mg/ml DMSO and 10mg/ml methanol.