GRAS Screen 4

1.0 mL of each 96 GRAS Screen 4 in a 96 deep well polypropylene microplate.
GRAS Screen 3 and GRAS Screen 4 were developed by Hampton Research for the crystallization of proteins, including monoclonal antibodies.
Each of the chemicals in GRAS Screen 3 and 4 have been used under one or more of the following categories. As (1) a Generally Recognized As Safe (GRAS) substance, (2) a pharmaceutical excipient, (3) a normal physiological constituent, (4) a metabolic byproduct, and/or (5) a Everything Added to Food in the United States (EAFUS) substance.
Formulation is based on a) data mining databases such as the Protein Data Bank (PDB), BMCD, and in house Hampton Research data, b) review and analysis of the patent and scientific literature, c) input from academic and pharma colleagues, and d) in house testing.
The primary crystallization reagent in GRAS Screen 3 and 4 are 24 unique salts (high concentration), versus Polyethylene glycol 300, 400, MME 550, 600, 1, 000, MME 2, 000, 3, 350 and 4, 000 as secondary reagents (low concentration), sampling pH 4 to 9 without an added buffer.
GRAS Screen 3 samples twenty four salts, encompassing pH 4-9 versus four low molecular weight Polyethylene glycols (300, 400, MME 550, & 600). GRAS Screen 3 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 3 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.
GRAS Screen 4 samples twenty four salts, encompassing pH 4-9 versus four medium molecular weight Polyethylene glycols (1, 000, MME 2, 000, 3, 350 & 4, 000). GRAS Screen 4 is supplied in a 96 Deep Well block format and is compatible with robotic and multi-channel pipet liquid handling systems. GRAS Screen 4 is compatible with vapor diffusion, free interface diffusion, and microbatch crystallization methods. For research use only.