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GCN2iB (acetate)

GCN2iB (acetate)

Item no.	HY-112654A
Manufacturer	MedChem Express
CASRN	2183470-13-3
Amount	1 ea
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Citations	[1]Activation of Gcn2 by small molecules designed to be inhibitors
Smiles	O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(C(C#CC3=CN=C(N=C3)N)=C2F)F)=O.CC(O)=O
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Endogenous Metabolite
Shipping Temperature	Room Temperature
Product Description	GCN2iB acetate is a GCN2 inhibitor that enhances Gcn2 activity and Atf4 expression. GCN2iB can activate Gcn2 mutants lacking functional regulatory regions or certain kinase domain substitution mutants. GCN2iB increases eIF2 phosphorylation by Gcn2 at low concentrations, thereby enhancing the cellular response to nutritional stress. GCN2iB may have potential benefits for the inhibition of cancer cells expressing low basal levels of aspartate synthetase, enhancing their sensitivity to the anti-leukemic compound L-aspartase[1].
Manufacturer - Research Area	cancer
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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