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(R)-Bromoenol lactone-d7

(R)-Bromoenol lactone-d7

Item no.	HY-117068S
Manufacturer	MedChem Express
Amount	1 ea
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14.
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	(R,E)-Bromoenol lactone-d7
Shipping condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Isotope-Labeled Compounds; Phospholipase
Shipping Temperature	Room temperature
Molecular Weight	324.22
Product Description	(R)-Bromoenol lactone-d7 ((R, E)-Bromoenol lactone-d7) is deuterium labeled (R)-Bromoenol lactone. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM[1][2].
Manufacturer - Research Area	Others
Manufacturer - Pathway	Metabolic Enzyme/Protease; Others
Clinical information	Phase 1

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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