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Locostatin

Locostatin

Item no.	LSHB-OP-2000002686-25mg
Manufacturer	Life Science Hub
CASRN	133812-16-5
Amount	25 mg
Category	Reagents & Chemicals APIs general
Type	Chemicals
Specific against	other
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Additional information - Category	Biochemical Compounds
Storage Conditions	-20°C
Storage Buffer	Off-white solid
Background	Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Description	Chemical Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone Molecular weight: 245.28 Formula: C14H15O3 Solubility: DMSO (60 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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