LCL161

Item no.	V0056-25mg
Manufacturer	InvivoChem LLC
CASRN	1005342-46-0
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0056CAS #:1005342-46-0Purity >=98% Description: LCL161 (LCL-161) is a novel and potent SMAC (second mitochondrial-derived activator of caspases) mimetic agent with potential anticancer activity, acting by potently binding to and inhibiting multiple IAP (inhibitor of apoptosis) proteins such as XIAP and c-IAP. It inhibits XIAP in HEK293 cells and cIAP1 in MDA-MB-231 cells with IC50s of 35 and 0.4 nM, respectively. LCL161 showed anti proliferative activities in two human hepatocellular carcinoma (HCC) cells, Hep3B and PLC5 with IC50 values of 10 and 19 uM, respectively. Description:(second mitochondrial-derived activator of caspases) References: Biochem Pharmacol. 2012 Aug 1; 84(3):268-77; Pediatr Blood Cancer. 2012 Apr; 58(4):636-9. References:
Molecular Weight (MW)	500.63
Formula	C26H33FN4O3S
CAS No.	1005342-46-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: Soluble in DMSO > 10 mM
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: 20 mg/mL warming (39.94 mM)
Other info	Synonym: LCL161; LCL 161; LCL-161 Chemical Name: (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide InChi Key: UFPFGVNKHCLJJO-SSKFGXFMSA-N InChi Code: InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13, 15-17, 21-22, 28H, 3-9, 14H2, 1-2H3, (H, 30, 33)/t16-, 21-, 22-/m0/s1 SMILES Code: C[CH](NC)C(N[CH](C1CCCCC1)C(N2[CH](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O
Chemical Name	(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1, 3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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