« Back
Home /
Salubrinal

Salubrinal

Item no.	V0058-10mg
Manufacturer	InvivoChem LLC
CASRN	405060-95-9
Amount	10 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0058CAS #:405060-95-9Purity >=98% Description: Salubrinal is a novel, potent, cell-permeable and selective inhibitor of eIF2alpha (eukaryotic translation initiation factor 2 subunit alpha) dephosphorylation with potential anticancer activity. It inhibits ER stress-mediated apoptosis with EC50 of ca.15 uM in cell-free assays. The eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) is crucial in protein synthesis. eIF2alpha phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2alpha. Salubrinal inhibits eIF2alpha dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ca. 3uM by inhibiting eIF2alpha dephosphorylation. Description: References: Science, 2005, 307(5711), 935-939.; Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184. References:
Molecular Weight (MW)	479.81
Formula	C21H17Cl3N4OS
CAS No.	405060-95-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 96 mg/mL (200.07 mM)
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: 2 mg/mL (4.16 mM)
Other info	InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N InChi Code: InChI=1S/C21H17Cl3N4OS/c22-21(23, 24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13, 19H, (H, 27, 29)(H2, 26, 28, 30)/b12-11+ SMILES Code: O=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3
Chemical Name	(E)-3-phenyl-N-[2, 2, 2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 13 days

Compare

Add to wishlist

Get an offer