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Description: Pifithrin-beta HBr (QB-102; Cyclic-Pifithrin-alpha), the hydrobromide salt of Pifithrin-beta, is a potent p53 inhibitor (IC50 of 23 uM) and a cell-permeable Cyclized analog of Pifithrin-alpha with higher stability and reduced cytotoxicity. Pifithrin-beta HBr has neuroprotective activity.
References: Bioorg Med Chem. 2011 Mar 1; 19(5):1649-57; ACS Chem Neurosci. 2014 May 21; 5(5): 390–399.
Related CAS: 60477-34-1 (free base); 2109248-93-1 (HCl)
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