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Duvelisib (IPI-145, INK1197)

Duvelisib (IPI-145, INK1197)

Item no.	V0127-250mg
Manufacturer	InvivoChem LLC
CASRN	1201438-56-3
Amount	250 mg
Quantity options	100 mg 10 mg 1 g 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0127CAS #:1201438-56-3Purity >=98% Description:Duvelisib (formerly known as IPI-145 and INK1197, trade name: Copiktra), an isoquinolinone derivative, is a novel potent, orally bioactive and selective small-molecule phosphoinositide-3 kinases (PI3K) inhibitor with potential anticancer activity. It selectively and potently inhibits two PI3K isoforms, PI3K-delta and PI3K-gamma, with IC50 of 2.5 nM and 27 nM respectively. In 2018, Duvelisib was approved by FDA to treat relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and follicular lymphoma. Description:Description: isoquinolinone derivative, is a novel potent, orally bioactive and selective small-molecule phosphoinositide-3 kinases (PI3K) inhibitor with potential anticancer activity. It selectively and potently inhibits two PI3K isoforms, PI3K-delta and PI3K-gamma, with IC50 of 2.5 nM and 27 nM respectively. In 2018, Duvelisib was approved by FDA to treat relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and follicular lymphoma. References: Chem Biol. 2013 Nov 21; 20(11):1364-74; Oncotarget. 2016 Jun 28; 7(26):39784-39795. References: References: Related CAS: 1261590-48-0 (R-isomer); 1386861-49-9 (hydrate)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 12/4/2025

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