« Back
Home /
Brefeldin A (BFA)

Brefeldin A (BFA)

Item no.	V0160-1g
Manufacturer	InvivoChem LLC
CASRN	20350-15-6
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0160CAS #:20350-15-6Purity >=98% Description: Brefeldin A (also known as BFA), a fungal metabolite, is a potent macrocyclic lactone antibiotic and ATPase inhibitor for intracellular vesicle formation and protein transport (protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus) with IC50 of 0.2 uM in HCT 116 cells. It has antitumor, antifungal, and antiviral effects. It induces cancer cell differentiation and apoptosis. Treatment with BFA could attenuate stimulus-dependent hyperalgesia phenomenon via inhibiting vesicular exocytosis which process is important for ATP release. BFA induced cells apoprosis (colorectal cancer cell line HCT116 ) by inhibiting ATP which functioned in the process of cellular vesicle trafficking. References: Bioorg Med Chem. 2000 Feb; 8(2):455-63; Leuk Res. 2007 Dec; 31(12):1687-700.
Molecular Weight (MW)	280.36
Formula	C16H24O4
CAS No.	20350-15-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 4 mg/mL (14.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (1S, 2E, 7S, 10E, 12R, 13R, 15S)-12, 15-Dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2, 10-dien-9-one InChi Key: KQNZDYYTLMIZCT-KQPMLPITSA-N InChi Code: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4, 6-8, 11-15, 17-18H, 2-3, 5, 9-10H2, 1H3/b6-4+, 8-7+/t11-, 12+, 13-, 14+, 15+/m0/s1 SMILES Code: O=C1O[CH](C)CCC/C=C/[C]2([H])C[CH](O)C[C]2([H])[CH](O)/C=C/1
Synonyms	Brefeldin A; BFA; Cyanein; Decumbin; Brefeldin-A; Ascotoxin; Cyanein; Decumbin; Bredfeldin A; Synergisidin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1 g

available

Delivery expected until 11/6/2025

Express Delivery: Save 15 days

Compare

Add to wishlist

Get an offer