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Sapanisertib (NK128; MLN0128; TAK228)

Sapanisertib (NK128; MLN0128; TAK228)

Item no.	V0185-250mg
Manufacturer	InvivoChem LLC
CASRN	1224844-38-5
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0185CAS #:1224844-38-5Purity >=98% Description: Sapanisertib (NK-128; MLN-0128; TAK-228) is a novel, potent, orally bioavailable and selective inhibitor of mTOR (mammalian target of rapamycin) with potential anticancer activity. It inhibits mTOR with an IC50 of 1 nM in cell-free assays. In a ZR-75-1 breast cancer xenograft model, INK 128 shows tumor growth inhibition efficacy at a dose of 0.3 mg/kg/day. Daily, oral administration of INK 128 inhibits angiogenesis and tumor growth in multiplexenograft models. Description:Description: Sapanisertib (NK-128; MLN-0128; TAK-228) is a novel, potent, orally bioavailable and selective inhibitor of mTOR (mammalian target of rapamycin) with potential anticancer activity. It inhibits mTOR with an IC50 of 1 nM in cell-free assays. In a ZR-75-1 breast cancer xenograft model, INK 128 shows tumor growth inhibition efficacy at a dose of 0.3 mg/kg/day. Daily, oral administration of INK 128 inhibits angiogenesis and tumor growth in multiplexenograft models.In a ZR-75-1 breast cancer xenograft model, INK 128 shows tumor growth inhibition efficacy at a dose of 0.3 mg/kg/day. Daily, oral administration of INK 128 inhibits angiogenesis and tumor growth in multiplexenograft models. References: Nature. 2012 Feb 22; 485(7396):55-61; Drug Discov Today Ther Strateg. 2009; 6(2):47-55. References:References:

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Amount: 250 mg

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Delivery expected until 9/4/2025

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