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Description: Torin 2 is a novel, potent and selective ATP-competitive inhibitor of mTOR (mammalian target of rapamycin) with potential antitumor activity. It inhibits mTOR with an IC50 of 0.25 nM in p53?/? MEFs cell line; It displayed ca.800-fold higher selectivity for mTOR over PI3K and possessed favorable pharmacokinetics.
References: J Med Chem. 2011 Mar 10; 54(5):1473-80; EMBO J. 2012 Mar 7; 31(5):1095-108; Clin Cancer Res. 2012 Jul 1; 18(13):3532-40.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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