Chrysophanic Acid (Chrysophanol)

Description: Chrysophanic acid (also called Chrysophanol), a naturally occuring anthraquinone isolated from Dianella longifolia, is a selective and potent inhibitor of EGFR/mTOR (epidermal growth factor (EGF) receptor/mammalian target of rapamycin) with potential anti-obesity and antitumor activity. Chrysophanol (CA) improves high-fat diet (HFD)-induced obesity in C57BL/6 Mice. It also showed potent antiproliferative and ancticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. It preferentially blocked proliferation of SNU-C5 cells but not in other cell lines with low levels of EGFR expression.

References: Phytother Res. 2011 Jun; 25(6):833-7; Antiviral Res. 2001 Mar; 49(3):169-78.