« Back
Home /
ML133 HCl

ML133 HCl

Item no.	V0210-50mg
Manufacturer	InvivoChem LLC
CASRN	1222781-70-5
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0210CAS #:1222781-70-5Purity >=98% Description: ML133 HCl, the hydrochloride salt of ML-133, is a novel, potent and selective inhibitor of the inward-rectifier potassium channel 2 (Kir2) identified from a high-throughput screening (HTS) of more than 300, 000 small molecules. It inhibits Kir2.1 with an IC50 of 1.8 uM (at pH 7.4) and 290 nM (at pH 8.5), and shows no/little effect on Kir1.1, Kir4.1 and Kir7.1. The K(ir) inward rectifying potassium channels have a broad tissue distribution and are implicated in a variety of functional roles. References: ACS Chem Biol. 2011 Aug 19; 6(8):845-56.
Molecular Weight (MW)	313.82
Formula	C19H19NO.HCl
CAS No.	1222781-70-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (200.8 mM)
	Water: < 1 mg/mL
	Ethanol: 6 mg/mL (19.1 mM)
InChI Key	NGQIBUUFXDPHKT-UHFFFAOYSA-N
Synonyms	ML-133 HCl; ML133 HCl; ML 133 HCl; ML133 hydrochloride; ML 133 hydrochloride; ML-133 hydrochloride; 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride, CID 781301 hydrochloride, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride, SID 85281105 hydrochloride, VU0404943-1 hydrchloride

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 9 days

Compare

Add to wishlist

Get an offer