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Laduviglusib (CHIR99021)

Laduviglusib (CHIR99021)

Item no.	V0211-50mg
Manufacturer	InvivoChem LLC
CASRN	252917-06-9
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0211CAS #:252917-06-9 Purity >=98% Description: CHIR-99021 (CT99021; CT-99021) is a novel, potent and orally bioavailable inhibitor of GSK-3alpha/beta (glycogen synthase kinase 3alpha/beta) with the potential to treat type 2 diabetes. It inhibits GSK-3alpha/beta with an IC50 of 10 nM/6.7 nM in cell-free assays, also is a Wnt/beta-catenin activator which induces autophagy. Oral gavage of CHIR-99021 (30mg/kg) enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hoursafter administration, while plasma insulin remains at or below controllevels. type 2 diabetes. It inhibits GSK-3alpha/betaOral gavage of CHIR-99021 (30mg/kg) enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hoursafter administration, while plasma insulin remains at or below controllevels. Reference: PLoS One. 2013; 8(3):e58501. Related CAS: 1782235-14-6 (3HCl); 2109414-84-6 (2HCl); 1797989-42-4 (HCl); 252917-06-9 (free base)
Molecular Weight (MW)	465.34
Formula	C22H18Cl2N8
CAS No.	252917-06-9 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mg/mL warmed (21.48 mM)
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: < 1 mg/mL (slightly soluble or insoluble)
Solubility (In vivo)	4% DMSO+30% PEG 300+ddH2O
Synonym	CHIR-73911 HCl; CHIR73911; CHIR 73911 hydrochloride ; CHIR-911; CHIR911; CHIR 911; CT- 99021; CT-99021; CT- 99021; GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021

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Amount: 50 mg

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