Gliquidone (AR-DF26)

Description: Gliquidone (also known as AR-DF 26; Glurenorm; Beglynor) is a potent ATP-sensitive K+ channel antagonist with potential anti0diabetic activity. It inhibits ATP-sensitive K + channel with an IC50 of 27.2 NM. As a sulfonylurea anti-diabetic drug , it is used in the treatment of diabetes mellitus type 2. In patients with type 2 diabetes mellitus, gliquidone reduced the mean plasma glucose levels by 15% and increased insulin levels by 40%. In Caucasian patients with new-onset diabetes mellitus (NODM) after kidney transplantation, gliquidone reduced fasting blood glucose (FBG) from 154 mg/dl to 120 mg/dl.

References: Fundam Clin Pharmacol. 1991; 5(2):107-15; Arzneimittelforschung. 1997 Mar; 47(3):247-52.

Synonym: Gliquidone; Glurenorm; Beglynor; Glikvidon; Glycvidon; Sanofi Synthelabo brand of gliquidone; Yamanouchi brand of gliquidone; AR-DF 26

IUPAC/Chemical Name: 1-cyclohexyl-3-[4-[2-(7-methoxy-4, 4-dimethyl-1, 3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea

InChi Key: LLJFMFZYVVLQKT-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34, 35)29-26(33)28-19-7-5-4-6-8-19/h9-14, 17, 19H, 4-8, 15-16H2, 1-3H3, (H2, 28, 29, 33)

SMILES Code: CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C