H 89 2HCl

Description: H 89 2HCl, the dihydrochloride salt of H 89 (H-89), is a novel, potent and cAMP-dependent inhibitor of PKA (protein kinase A) with the potential to attenuates prominent behavioral signs of morphine withdrawal in morphine-dependent mice. It inhibits PKA with a Ki of 48 nM in a cell-free assay, shows 10-fold selectivity for PKA over PKG, and exhibits 500-fold higher selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.

References:J Biol Chem. 1990 Mar 25; 265(9):5267-72; Cardiovasc Drug Rev. 2006 Fall-Winter; 24(3-4):261-74.

Related CAS #: 127243-85-0 (free base); 1000995-75-4 (free base); 1049740-55-7 (2HCl hydrate)