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Dorsomorphin (BML275)

Dorsomorphin (BML275)

Item no.	V0251-50mg
Manufacturer	InvivoChem LLC
CASRN	866405-64-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0251CAS #:866405-64-3Purity >=98% Description: Dorsomorphin (BML-275) isa reversible and selective AMPK (AMP-activated protein kinase)inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such asZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin is also an inhibitor of BMPsignaling, which promotes cardiomyogenesis in embryonic stem cells.Dorsomorphin reverses the mesenchymal phenotype of breast cancerinitiating cells by inhibition of bone morphogenetic protein signaling. Description:Description: Dorsomorphin isa reversible and selective AMPK (AMP-activated protein kinase)inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such asZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin is also an inhibitor of BMPsignaling, which promotes cardiomyogenesis in embryonic stem cells.Dorsomorphin reverses the mesenchymal phenotype of breast cancerinitiating cells by inhibition of bone morphogenetic protein signaling. References: Nat Chem Biol. 2008 Jan; 4(1):33-41; J Biol Chem. 2006 Nov 17; 281(46):34870-9. References: References: Related CAS #: 866405-64-3 (free base); 1219168-18-9 (HCl) :

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Amount: 50 mg

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Delivery expected until 9/4/2025

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