Tubastatin A (TubA, AG-CR1-3900)

Description: Tubastatin A (TubA, AG-CR13900), a tubacin derivative, is a potent and selective HDAC6 (Histone deacetylase 6) inhibitor (IC50 = 15 nM in a cell-free assay) with potential anticancer and anti-inflammatory activity. It demonstrated the highest selectivity of over 1, 000-fold for HDAC6 over other HDAC isoforms (excluding HDAC8 for which the IC50 is 0.9 uM).

References: Cancer Res. 2013 Apr 1; 73(7):2259-70; Int Immunopharmacol. 2013 May; 16(1):72-8; Blood. 2012 Mar 15; 119(11):2579-89.

Related CAS #: 1252003-15-8 (free base); 1310693-92-5 (HCl);

Publications Citing Use of InvivoChem Tubastatin A HCl: Scientific Reports | (2020) 10:6064 | https://doi.org/10.1038/s41598-020-62678-5

Tubastatin A hydrochloride; Tubastatin A HCl; TSA HCl; Tubastatin A; TubA, AG-CR1-3900

Chemical Name: N-hydroxy-4-((2-methyl-3, 4-dihydro-1H-pyrido[4, 3-b]indol-5(2H)-yl)methyl)benzamide

InChi Key: GOVYBPLHWIEHEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9, 25H, 10-13H2, 1H3, (H, 21, 24)

SMILES Code: O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1