Givinostat HCl monohydrate (ITF-2357; Gavinostat))

Description: Givinostat (formerly ITF2357; Gavinostat) is a potent and orally bioavailable inhibitor of both class I and class II histone deacetylase (HDAC) with potential anticancer activity. It inhibits HDAC with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat is also a potent inhibitor of hematopoietic colony formation by JAKEV617F-bearing progenitor cells from chronic myeloproliferative neoplasms in vitro.

References: Mol Med. 2005 Jan-Dec; 11(1-12):1-15; Leukemia. 2007 Sep; 21(9):1892-900; Mol Med. 2011 May-Jun; 17(5-6):369-77.

Related CAS: 732302-99-7 (HCl hydrate); 497833-27-9 (free base); 199657-29-9 (HCl)

ITF2357; ITF 2357; ITF-2357; Givinostat ; gavinostat; ITF2357 HCl; ITF2357 hydrochloride; Givinostat HCl

Chemical Name: (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate

InChi Key: FKGKZBBDJSKCIS-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30; ; /h5-14, 30H, 3-4, 15-16H2, 1-2H3, (H, 25, 29)(H, 26, 28); 1H; 1H2

SMILES Code: ONC(C1=CC=C(C=C1)NC(OCC2=CC3=C(C=C2)C=C(CN(CC)CC)C=C3)=O)=O.[H]Cl.[H]O[H]