KC7F2

Item no.	V0299-1g
Manufacturer	InvivoChem LLC
CASRN	927822-86-4
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0299CAS #:927822-86-4Purity >=98% Description: KC7F2 is a novel and potent HIF-1 (hypoxia inducible factor-1) pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic agent to a variety of cancer cell lines with an IC50 value of 15-25 uM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2, endothelin 1, and enolase 1. Description: Description: KC7F2 is a novel and potent HIF-ay inhibitor with potential anticancer activity. KC7F2 is cytotoxic agent to a variety of cancer cell lines with an IC50 value of 15-25 uM. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2, endothelin 1, and enolase 1. References:Clin Cancer Res. 2009 Oct 1; 15(19):6128-36; Neuropharmacology. 2014 Feb; 77:428-40; Synapse. 2014 Sep; 68(9):402-9. References:References:

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