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Talazoparib (BMN 673; MDV3800)

Talazoparib (BMN 673; MDV3800)

Item no.	V0304-50mg
Manufacturer	InvivoChem LLC
CASRN	1207456-01-6
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 1 mg 250 mg 25 mg 2 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0304CAS #:1207456-01-6 Purity >=98% Description: Talazoparib (formerly BMN-673 and MDV-3800; trade name: Talzenna), is a novel, highly potent and orally bioavailable PARP1/2 poly(ADP-ribose) polymerase inhibitor approved for cancer treatment. It has favorable metabolic stability, oral bioavailability, and pharmacokinetic properties. As a novel PARP inhibitor, Talazoparib has an IC50 of 0.58 nM in a cell-free assay. It selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. On Oct 16 2018, Talazoparib was approved by the US FDA for the treatment of locally advanced or metastatic breast cancer patients with a germline BRCA mutation. Description: References: Clin Cancer Res. 2013 Sep 15; 19(18):5003-15; Clin Cancer Res. 2014 Apr 15; 20(8):2237. References: Related CAS: 1373431-65-2 (tosylate); 1207454-56-5; 1207456-00-5 (racemic mixture); 1207456-01-6 (free base)
Molecular Weight (MW)	380.35
Formula	C19H14F2N6O
CAS No.	1207456-01-6 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 38 mg/mL (99.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (8S, 9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1, 2, 4-triazol-5-yl)-8, 9-dihydro-2H-pyrido[4, 3, 2-de]phthalazin-3(7H)-one SMILES Code: O=C1NN=C2C3=C1C=C(F)C=C3N[CH](C4=CC=C(F)C=C4)[CH]2C5=NC=NN5C
Synonyms	BMN 673; BMN673; MDV-3800; MDV 3800; MDV3800; BMN-673; LT673; LT 673; LT-673; Talazoparib; trade name: Talzenna

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Amount: 50 mg

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Delivery expected until 9/4/2025

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