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G007-LK

G007-LK

Item no.	V0307-100mg
Manufacturer	InvivoChem LLC
CASRN	1380672-07-0
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0307CAS #:1380672-07-0Purity >=98% Description: G007-LK is a novel, potent and specific tankyrase (TNKS) 1/2 inhibitor with potential anticancer activity. It inhibits TNKS 1/2 with IC50s of 46 nM and 25 nM, respectively. G007-LK reduced auto-poly-(ADP ribosy)lation of TNKS1 and TNKS2. It shows potent antiproliferative activity against various cancer cells and high in vivo antitumor efficacy as well. In Wnt3a-induced HEK 293 cells, G007-LK inhibited ST-Luc with IC50 value of 0.05 uM. In SW480 colorectal cancer cell line transfected with GFP-TNKS1, G007-LK induces highly dynamic and mobile degradasomes containing phosphorylated beta-catenin, beta-TrCP and ubiquitin. In the APC-mutant cell lines, G007-LK reduces cytosolic and nuclear beta-catenin protein levels. Description: References: J Med Chem. 2013 Apr 11; 56(7):3012-23; Cancer Res. 2013 May 15; 73(10):3132-44. References:
Molecular Weight (MW)	529.96
Formula	C25H16ClN7O3S
CAS No.	1380672-07-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (188.7 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1, 2, 4-triazol-3-yl)vinyl)-1, 3, 4-oxadiazol-2-yl)benzonitrile InChi Key: HIWVLHPKZNBSBE-OUKQBFOZSA-N InChi Code: InChI=1S/C25H16ClN7O3S/c1-37(34, 35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13, 15H, 1H3/b13-12+ SMILES Code: N#CC1=CC=C(C2=NN=C(/C=C/C3=NN=C(C4=NC=C(S(=O)(C)=O)C=C4)N3C5=CC=CC=C5Cl)O2)C=C1
Synonyms	G00 7LK; G007-LK; G007LK

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 9/4/2025

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