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AZD2461

AZD2461

Item no.	V0310-50mg
Manufacturer	InvivoChem LLC
CASRN	1174043-16-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0310CAS #:1174043-16-3Purity >=98% Description: AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity. In inhibits PARP1/2/3 with IC50 values of 5 nM, 2 nM and 200 nM, respectively. It is a poor substrate of P-glycoprotein and was developed as a 2nd-generation compound of olaparib. Description: References: Cancer Res. 2016 Oct 15; 76(20):6084-6094; Br J Pharmacol. 2009 Jul; 157(5):854-62. References:
Molecular Weight (MW)	395.43
Formula	C22H22FN3O3
CAS No.	1174043-16-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES Code	O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=C1C=CC=C4
Synonyms	AZD 2461; AZD-2461; AZD2461; 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one InChi Key: HYNBNUYQTQIHJK-UHFFFAOYSA-N InChi Code: InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7, 12, 15H, 8-11, 13H2, 1H3, (H, 25, 27) SMILES Code: O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=C1C=CC=C4

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 11/6/2025

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