Comparison

PJ34 HCl

Item no. V0311-1g
Manufacturer InvivoChem LLC
CASRN 344458-15-7
Amount 1 g
Quantity options 100 mg 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Available
Description
InvivoChem Cat #:V0311CAS #:344458-15-7Purity >=98%

Description: PJ34 HCl, the hydrochloride of PJ34, is a novel, potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP) with potential anticancer and neuro-protective activities. It inhibits PARP with an EC50 value of 20 nM in a cell-free assay. PJ34 has neuro-protective effects and can enhance the chemotherapeutic effects in several tumor types.

Description:

References: Nat Med. 2001 Jan; 7(1):108-13; J Pharmacol Exp Ther. 2004 Sep; 310(3):1053-61.

References:

Related CAS #: 344458-19-1 (free base); 344458-15-7 (HCl);

Molecular Weight (MW)
331.8
Formula
C17H17N3O2.HCl
CAS No.
344458-15-7
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 66 mg/mL (198.9 mM)
Water: 66 mg/mL (198.9 mM)
Ethanol: < 1 mg/mL
Solubility (In vivo)
30% PEG400+0.5% Tween80+5% propylene glycol: 14 mg/mL
Synonyms

Synonym: PJ-34; PJ34; PJ 34; PJ-34 HCl; PJ-34 hydrochloride.

Chemical Name: 2-(dimethylamino)-N-(6-oxo-5, 6-dihydrophenanthridin-2-yl)acetamide hydrochloride

InChi Key: RURAZZMDMNRXMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15; /h3-9H, 10H2, 1-2H3, (H, 18, 21)(H, 19, 22); 1H

SMILES Code: O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 g
Available: In stock
available

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