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Description: Curcumol is a selective, potent, naturally occuring and pure monomer isolated from Rhizoma Curcumaeis with potential antitumor activities. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy.vAs an inducer of apoptosis, curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis.
References: Med Oncol. 2011 Mar; 28(1):307-14; Evid Based Complement Alternat Med. 2012; 2012:746426.
Chemical Name: (3S, 3aS, 5S, 6R, 8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a, 6-epoxyazulen-6-ol
InChi Key: QRMPRVXWPCLVNI-YYFQZIEXSA-N
InChi Code: InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13, 16)17-14/h9, 11-13, 16H, 3, 5-8H2, 1-2, 4H3/t11-, 12-, 13-, 14-, 15+/m0/s1
SMILES Code: O[C]1(C2)[CH](C(C)C)C[C]3(O1)[CH](C)CC[C]3([H])C2=C
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