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MK-8745

MK-8745

Item no.	V0352-50mg
Manufacturer	InvivoChem LLC
CASRN	885325-71-3
Amount	50 mg
Quantity options	100 mg 1 g 250 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0352CAS #:885325-71-3Purity >=98% Description: MK-8745 is a novel, potent, specific and selective Aurora A inhibitor with potential antitumor activity. It inhibits Aurora A with an IC50 of 0.6 nM, and is 450-fold more selective for Aurora A over Aurora B. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. p53-dependent apoptosis by MK8745 was further confirmed in HCT 116 p53(-/-) cells transfected with wild-type p53. Description: References: Leuk Lymphoma. 2012 Mar; 53(3):462-71; Cell Cycle. 2012 Feb 15; 11(4):807-17. References:
Molecular Weight (MW)	431.91
Formula	C20H19ClFN5OS
CAS No.	885325-71-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 86 mg/mL (199.1 mM)
	Water: < 1 mg/mL
	Ethanol: 1 mg/mL (2.3 mM)
Other info	Chemical Name: (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone. InChi Key: YCRFPWKUUNKNDN-UHFFFAOYSA-N InChi Code: InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7, 12H, 8-11, 13H2, (H, 23, 24, 25) SMILES Code: O=C(C1=CC=CC(Cl)=C1F)N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2
Synonyms	MK 8745; MK8745; MK-8745

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Amount: 50 mg

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Delivery expected until 9/4/2025

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