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SNS-314 Mesylate

SNS-314 Mesylate

Item no.	V0367-50mg
Manufacturer	InvivoChem LLC
CASRN	1146618-41-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0367CAS #:1146618-41-8Purity >=98% Description: SNS-314 mesylate, the mesylate salt of SNS314, is a pan-Aurora kinase inhibitor with potential antineoplastic activity. It inhibits Aurora A/B/C with IC50s of 9 nM, 31 nM, and 3 nM, respectively. SNS 314 exhibits excellent antiproliferative activity and high in vivo antitumor efficacy. Description: References: Mol Cancer Ther. 2009 Apr; 8(4):930-9; Cancer Chemother Pharmacol. 2010 Mar; 65(4):707-17. References: Related CAS: 1146618-41-8 (mesylate); 1057249-41-8 (free base)
Molecular Weight (MW)	527.04
Formula	C18H15ClN6OS2.CH4O3S
CAS No.	1146618-41-8 (mesylate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 105 mg/mL (199.2 mM)
	Water: 6 mg/mL (11.4 mM)
	Ethanol: < 1 mg/mL
Solubility (In vivo)	15% Captisol: ca.6 mg/mL
Synonyms	SNS314; SNS 314; SNS-314; SNS-314 mesylate Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3, 2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea mesylate InChi Key: FYCODPVDEFFWSR-UHFFFAOYSA-N InChi Code: InChI=1S/C18H15ClN6OS2.CH4O3S/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16; 1-5(2, 3)4/h1-3, 5, 7-10H, 4, 6H2, (H, 20, 22, 23)(H2, 21, 24, 25, 26); 1H3, (H, 2, 3, 4) SMILES Code: O=C(NC1=NC=C(CCNC2=C3C(C=CS3)=NC=N2)S1)NC4=CC=CC(Cl)=C4.OS(=O)(C)=O

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Amount: 50 mg

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