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Ranolazine 2HCl (RS-43285; CVT-303)

Ranolazine 2HCl (RS-43285; CVT-303)

Item no.	V0368-2g
Manufacturer	InvivoChem LLC
CASRN	95635-56-6
Amount	2 g
Quantity options	1 g 250 mg 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0368CAS #:95635-56-6Purity >=98% Description: Ranolazine 2HCl (known also as Ranolazine diHydrochloride), the diHCl salt of ranolzaine (RS43285; CVT303), is a an anti-angina drug which acts as a potent calcium uptake inhibitor via the sodium/calcium channel, it is used to treat chronic angina. Ranolazine is an anti-ischemic agent that inhibits late sodium current that results in a reduction of Na+ dependent Ca2+ overload. Ranolazine can cause the shift of ATP production towards glucose oxidation, which is due to the fact that more oxygen is required to phosphorylate the same amount of ATP during fatty acid oxidation than carbohydrate oxidation. These studies indicate that Ranolazine also inhibits oxygen consumption and ketogenesis by fatty acids in liver cells. References: Heart. 2006 Jul; 92 Suppl 4:iv6-iv14; Circulation. 1996 Jan 1; 93(1):135-42. Related CAS #: 95635-56-6 (HCl); 95635-55-5 (free base)
Molecular Weight (MW)	500.46
Formula	C24H33N3O4.2HCl
CAS No.	95635-56-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.8 mM)
	Water: 100 mg/mL (199.8 mM)
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: N-(2, 6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride InChi Key: RJNSNFZXAZXOFX-UHFFFAOYSA-N InChi Code: InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3; ; /h4-10, 20, 28H, 11-17H2, 1-3H3, (H, 25, 29); 2*1H SMILES Code: O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl
Synonyms	RS-43285; RS43285; RS 43285; CVT 303; CVT303; CVT-303; Ranolazine; Ranexa; Latixa; Ranolazine Dihydrochloride; Ranolazine Hydrochloride; Ranolazine HCl; .

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Amount: 2 g

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