IOX1

Item no.	V0372-250mg
Manufacturer	InvivoChem LLC
CASRN	5852-78-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0372CAS #:5852-78-8Purity >=98% Description: IOX1 (5-Carboxy-8-hydroxyquinoline) is a novel, potent and broad-spectrum inhibitor of 2OG oxygenases (e.g. JMJD and JmjC demethylases) with anticancer activity. In MALDI-TOF MS assay, IOX 1 inhibited JMJD2E, JMJD2A, FIH and PHD2 with IC50 values of 2.4, 1.7, 20.5 and 14.3 uM, respectively. In HeLa cells, IOX 1 increased H3K9me3 fluorescence intensity, suggesting that IOX 1 inhibited H3K9me3 demethylation induced by JMJD2A with IC50 value of 86.5 uM. Description: References: ChemMedChem. 2014 Mar; 9(3):566-71. References:
Molecular Weight (MW)	189.17
Formula	C10H7NO3
CAS No.	5852-78-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 37 mg/mL (195.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 8-Hydroxyquinoline-5-carboxylic acid InChi Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N InChi Code: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5, 12H, (H, 13, 14) SMILES Code: O=C(C1=C2C=CC=NC2=C(O)C=C1)O
Synonyms	IOX-1; IOX 1; IOX1

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Amount: 250 mg

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